abstract：:The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotyp...

journal_title：Journal of medical virology

authors： Deterding K,Constantinescu I,Nedelcu FD,Gervain J,Nemecek V,Srtunecky O,Vince A,Grgurevic I,Bielawski KP,Zalewska M,Bock T,Ambrozaitis A,Stanczak J,Takács M,Chulanov V,Slusarczyk J,Drazd'áková M,Wiegand J,Cornberg M,

更新日期：2008-10-01 00:00:00

abstract：:Hemorrhagic fever with renal syndrome (HFRS) is a severe acute viral disease with pathological changes of impaired capillary and small vessels and thrombocytopenia. In this study, serum thrombospondin (TSP)-1 concentration in patients with HFRS was determined to explore its possible role in the pathogenesis of HFRS. T...

journal_title：Journal of medical virology

authors： Liu Z,Zhao Q,Han Q,Gao M,Zhang N

更新日期：2008-10-01 00:00:00

abstract：:Despite the success of antivirals in preventing clinically overt CMV disease in cardiac allograft recipients, sub-clinical active CMV infection remains a major concern because of its association with allograft rejection and vasculopathy. The measurement of CMV specific T-cell responses is a promising approach to asses...

journal_title：Journal of medical virology

authors： Kirchner A,Hoffmeister B,Cherepnev-G G,Fuhrmann S,Streitz M,Lachmann R,Bunde T,Meij P,Schönemann C,Hetzer R,Lehmkuhl HB,Volkmer-Engert R,Volk HD,Gratama JW,Kern F

更新日期：2008-09-01 00:00:00

abstract：:The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...

journal_title：Journal of medical virology

authors： Nicot F,Legrand-Abravanel F,Lafont T,Dubois M,Sauné K,Pasquier C,Chatelut E,Izopet J

更新日期：2008-09-01 00:00:00

abstract：:From November 2004 to April 2007, specimens were obtained from 2,281 patients with acute respiratory tract illness in Normandy, France. Eighteen strains of influenza C virus were detected in these samples using a combined tissue culture/RT-PCR diagnostic method. Most patients with influenza C virus infection (13/18) w...

journal_title：Journal of medical virology

authors： Gouarin S,Vabret A,Dina J,Petitjean J,Brouard J,Cuvillon-Nimal D,Freymuth F

更新日期：2008-08-01 00:00:00

abstract：:The efficacy of interferon (IFN) monotherapy for non-responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who received low-dose intermittent IFN-...

journal_title：Journal of medical virology

authors： Akuta N,Suzuki F,Kawamura Y,Yatsuji H,Sezaki H,Suzuki Y,Hosaka T,Kobayashi M,Kobayashi M,Arase Y,Ikeda K,Kumada H

更新日期：2008-08-01 00:00:00

abstract：:The evidence on genotype-specific risk in women infected with human papillomavirus (HPV) with normal cytology and the importance of the distinction of high-risk (HR)-HPV genotypes in the management of low-grade lesions suggest that the distinction of HR-HPV genotypes has the potential to improve the follow-up of patie...

journal_title：Journal of medical virology

authors： Venturoli S,Ambretti S,Cricca M,Leo E,Costa S,Musiani M,Zerbini M

更新日期：2008-08-01 00:00:00

abstract：:A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44,827 of the Smith MCMV BAC, was attenuated in replication both in tis...

journal_title：Journal of medical virology

authors： Baluchova K,Kirby M,Ahasan MM,Sweet C

更新日期：2008-07-01 00:00:00

abstract：:The relationships between host immune factors and HIV-1 disease progression are still in dispute. The RANTES SNPs exhibit distinct ethnic distribution and are associated with different effects on the course of HIV infection. Therefore, impact of RANTES gene polymorphism on HIV-1 transmission and progression needs to b...

journal_title：Journal of medical virology

authors： Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Singhal PK,Dhole TN

更新日期：2008-07-01 00:00:00

abstract：:During 2002, an upsurge in frequency of hepatitis A outbreaks among injecting drug users was observed in England and Wales. As lack of risk factor information and the high mobility of the cases made linkage of outbreaks difficult, the relationship of nucleotide sequences in the VP1/2PA junction of the hepatitis A viru...

journal_title：Journal of medical virology

authors： Ngui SL,Granerod J,Jewes LA,Crowcroft NS,Teo CG,2002 Hepatitis A Outbreaks Investigation Network.

更新日期：2008-07-01 00:00:00

abstract：:Varicella zoster virus (VZV) causes varicella (chickenpox), after which virus becomes latent in ganglia along the entire neuraxis. Virus reactivation produces zoster (shingles). Infectious VZV is found in vesicles of patients with zoster and varicella, but virus shed in the absence of disease has not been documented. ...

journal_title：Journal of medical virology

authors： Cohrs RJ,Mehta SK,Schmid DS,Gilden DH,Pierson DL

更新日期：2008-06-01 00:00:00

abstract：:The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the ...

journal_title：Journal of medical virology

authors： Kmieciak D,Debicki S,Trzeciak WH

更新日期：2008-06-01 00:00:00

abstract：:Stored demographic data and HIV RT and protease sequences of 877 HIV patients attending for the first time the HIV/AIDS outpatient clinics of a reference Infectious Diseases centre in Northern Italy between 1999 and 2006 were stratified by 3-year spanning periods according to date of HIV infection. In the period 1980-...

journal_title：Journal of medical virology

authors： Baldanti F,Paolucci S,Ravasi G,Maccabruni A,Moriggia A,Barbarini G,Maserati R

更新日期：2008-06-01 00:00:00

abstract：:Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in ...

journal_title：Journal of medical virology

authors： Yun H,Kim S,Lee H,Byun KS,Kwon SY,Yim HJ,Lim YS,Jeong SH,Jee Y

更新日期：2008-05-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...

journal_title：Journal of medical virology

authors： Yoshizaki T,Wakisaka N,Kondo S,Murono S,Shimizu Y,Nakashima M,Tsuji A,Furukawa M

更新日期：2008-05-01 00:00:00

abstract：:Resistance to adamantanes for treating influenza A(H3N2) has increased dramatically, worldwide, over the past 5 years. A comprehensive 10-year data set on the rise of adamantane-resistance in Hong Kong is reported. Nucleotide sequences encoding the M2-ion channel of influenza A(H3N2) were obtained from 281 H3N2 isolat...

journal_title：Journal of medical virology

authors： Tang JW,Ngai KL,Wong JC,Lam WY,Chan PK

更新日期：2008-05-01 00:00:00

abstract：:The metastasis status of pelvic lymph nodes (PLNs) seems to be a predictive factor of survival. It was suggested that the presence of HPV DNA and other biological markers in PLN may indicate a sub clinical early metastasis. The aim was to describe the prevalence and distribution patterns of HPV DNA and H-ras mutations...

journal_title：Journal of medical virology

authors： Landro ME,Dalbert D,Picconi MA,Cúneo N,González J,Vornetti S,Bazán G,Mural J,Basiletti J,Teyssié AR,Alonio LV

更新日期：2008-04-01 00:00:00

abstract：:Hepatitis E virus (HEV), the sole member of the genus Hepevirus in the family of Hepeviridae, is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis in endemic and industrialized countries. Transmission of HEV occurs predominantly ...

journal_title：Journal of medical virology

authors： Mushahwar IK

更新日期：2008-04-01 00:00:00

abstract：:A total of 190 specimens from South Indian children aged 0-59 months with ocular anomalies consistent with suspected congenital rubella syndrome (CRS) were investigated. Twenty-six of the 65 infants (40%) were confirmed as CRS by detection of rubella specific IgM. Rubella RNA was detected in 41 samples from 26 infants...

journal_title：Journal of medical virology

authors： Rajasundari TA,Sundaresan P,Vijayalakshmi P,Brown DW,Jin L

更新日期：2008-03-01 00:00:00

abstract：:Rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative PCRs. Quantitative PCR assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), a...

journal_title：Journal of medical virology

authors： Engelmann I,Petzold DR,Kosinska A,Hepkema BG,Schulz TF,Heim A

更新日期：2008-03-01 00:00:00

abstract：:DNA plasmids are potent inducers of long-lasting antigen-specific CTL responses. Little is known about the distribution of antigen-specific CD8+ T cells in the lymphoid tissue and the non-lymphoid tissue after DNA immunization. HBsAg-specific CD8+ T cells in peripheral blood mononuclear cells, spleen, lymph nodes, and...

journal_title：Journal of medical virology

authors： Qu D,Lanier G,Yuan ZH,Wen YM,Howard CR,Ahmed R

更新日期：2008-02-01 00:00:00

abstract：:As a consequence of the high prevalence of TorqueTeno virus (TTV) in blood donors, thalassemia patients frequently acquire various genotypes of this virus through therapeutic blood transfusions. At present, the clinical consequences of TTV infection remain indeterminate for these patients. Here, several hundred thalas...

journal_title：Journal of medical virology

authors： Hu YW,Al-Moslih MI,Al Ali MT,Uzicanin S,Perkins H,Yi QL,Rahimi Khameneh S,Wu J,Brown EG

更新日期：2008-02-01 00:00:00

abstract：:A molecular epidemiological study on common diarrheal viruses was conducted in a children's hospital in Ho Chi Minh City between December 2005 and November 2006. Fecal samples were collected from 502 pediatric patients with acute gastroenteritis, and were screened for eight types of viral agents. Human astroviruses (H...

journal_title：Journal of medical virology

authors： Nguyen TA,Hoang L,Pham le D,Hoang KT,Mizuguchi M,Okitsu S,Ushijima H

更新日期：2008-02-01 00:00:00

abstract：:GB virus-B (GBV-B) is the virus most closely related to hepatitis C virus (HCV). Thus, we have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin...

journal_title：Journal of medical virology

authors： Bukh J,Engle RE,Govindarajan S,Purcell RH

更新日期：2008-01-01 00:00:00

abstract：:Maternal injection drug use and peripheral blood mononuclear cell infection by hepatitis C virus are important risk factors for perinatal transmission of the virus. The aim of present study was to evaluate the independent association of these two factors on perinatal transmission. Forty-eight consecutive mothers who t...

journal_title：Journal of medical virology

authors： Azzari C,Moriondo M,Indolfi G,Betti L,Gambineri E,de Martino M,Resti M

更新日期：2008-01-01 00:00:00

abstract：:Human metapneumovirus, with two known genotypes named A and B, is associated with mild respiratory symptoms to severe LRTI in children, high-risk adults and the elderly. Rapid and reliable methods of hMPV detection in clinical samples are essential to implement appropriate care, to better understand the pathology of h...

journal_title：Journal of medical virology

authors： Manoha C,Bour JB,Pitoiset C,Darniot M,Aho S,Pothier P

更新日期：2008-01-01 00:00:00

abstract：:Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance. Over 700 physicians from 75% of basic administrative units of Taiwan participated in the "Sentinel Physician Surveillance of Infectious Disease" and reported weekly to the Center ...

journal_title：Journal of medical virology

authors： Tseng FC,Huang HC,Chi CY,Lin TL,Liu CC,Jian JW,Hsu LC,Wu HS,Yang JY,Chang YW,Wang HC,Hsu YW,Su IJ,Wang JR,CDC-Taiwan Virology Reference Laboratories and Sentinel Physician Network.

更新日期：2007-12-01 00:00:00

abstract：:The human respiratory syncytial virus (HRSV) is the most important cause of admission to hospital for acute lower respiratory tract infections in infants and young children worldwide. Only few studies have investigated the molecular evolution of HRSV, and none has been conduct ed in Italy. The genetic diversity of the...

journal_title：Journal of medical virology

authors： Montieri S,Puzelli S,Ciccozzi M,Calzoletti L,Di Martino A,Milia MG,Rossi A,Piro F,Rezza G,Donatelli I

更新日期：2007-12-01 00:00:00

abstract：:Development of hepatitis B virus (HBV)-resistant strains following nucleos(t)ide analog treatment is a major medical concern. This report describes a case of an adult patient with chronic HBV infection, sequentially treated with the nucleos(t)ide analogues, lamivudine, adefovir, and entecavir. During monotherapy with ...

journal_title：Journal of medical virology

authors： Rodriguez-Frias F,Jardi R,Schaper M,Gimferrer M,Elefsiniotis I,Tabernero D,Esteban R,Buti M

更新日期：2007-11-01 00:00:00

abstract：:This was an exploratory study to investigate lamivudine-resistant hepatitis B virus (HBV) strains in selected lamivudine-naïve HBV carriers with and without human immunodeficiency virus (HIV) co-infection in South African patients. Thirty-five lamivudine-naïve HBV infected patients with or without HIV co-infection wer...

journal_title：Journal of medical virology

authors： Selabe SG,Lukhwareni A,Song E,Leeuw YG,Burnett RJ,Mphahlele MJ

更新日期：2007-11-01 00:00:00

abstract：:Despite prolonged undetectable plasma viral load some HIV-1 infected patients have been reported to develop resistance-associated mutations leading to treatment failure. The mechanisms for this phenomenon and the point of origin for residual viral evolution are still not elucidated. In order to quantify cell-associate...

journal_title：Journal of medical virology

authors： Kupfer B,Matz B,Däumer MP,Roden F,Rockstroh JK,Qurishi N,Spengler U,Kaiser R

更新日期：2007-10-01 00:00:00

abstract：:The S RNA genome segment of hantaviruses carried by Arvicolinae and Sigmodontinae rodents encodes the nucleocapsid (N) protein and has an overlapping (+1) open reading frame (ORF) for a putative nonstructural protein (NSs). The aim of this study was to determine whether the ORF is functional. A protein corresponding t...

journal_title：Journal of medical virology

authors： Jääskeläinen KM,Kaukinen P,Minskaya ES,Plyusnina A,Vapalahti O,Elliott RM,Weber F,Vaheri A,Plyusnin A

更新日期：2007-10-01 00:00:00

abstract：:It was reported previously that HCV can be transmitted from persistently infected human bone-marrow-derived B-lymphoblastoid cells (TO.FE(HCV)) to human hepatoma cells by cell-to-cell contact. The present study confirms and characterize further such type of HCV infection in vitro. TO.FE(HCV) cells were co-cultured wit...

journal_title：Journal of medical virology

authors： Valli MB,Crema A,Lanzilli G,Serafino A,Bertolini L,Ravagnan G,Ponzetto A,Menzo S,Clementi M,Carloni G

更新日期：2007-10-01 00:00:00

abstract：:The objective of this study was to investigate variation in human papillomavirus (HPV) type-16 load within histologically defined grades of cervical intraepithelial neoplasia. Two hundred and thirty-seven liquid based cytology samples were collected from women attending colposcopy clinics, DNA was extracted, and prese...

journal_title：Journal of medical virology

authors： Fiander AN,Hart KW,Hibbitts SJ,Rieck GC,Tristram AJ,Beukenholdt RW,Powell NG

更新日期：2007-09-01 00:00:00

abstract：:Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...

journal_title：Journal of medical virology

authors： Banerjee I,Ramani S,Primrose B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

更新日期：2007-09-01 00:00:00

abstract：:An epidemiological and molecular study of hepatitis C virus (HCV) infection was carried out in Brazilian hemodialysis centers. A total of 1,095 patients in all 15 hemodialysis centers in the State of Goiás, Brazil, were studied. All patients were interviewed for possible risk factors to HCV infection and serum samples...

journal_title：Journal of medical virology

authors： Carneiro MA,Teles SA,Lampe E,Espírito-Santo MP,Gouveia-Oliveira R,Reis NR,Yoshida CF,Martins RM

更新日期：2007-09-01 00:00:00

abstract：:To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...

journal_title：Journal of medical virology

authors： Tanzi E,Amendola A,Pariani E,Zappa A,Colzani D,Logias F,Perego A,Zanetti AR

更新日期：2007-08-01 00:00:00

abstract：:The efficacy of interferon therapy for hepatitis C virus (HCV) infection improved remarkably. However, virologic relapse occurs in a substantial proportion of patients with virologic response (defined as an HCV RNA level below 50 IU/ml at the end-of-treatment). A highly sensitive RT-nested PCR assay capable of detecti...

journal_title：Journal of medical virology

authors： Kinai E,Hanabusa H,Kato S

更新日期：2007-08-01 00:00:00

abstract：:Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In ...

journal_title：Journal of medical virology

authors： Ding L,Li L,Yang J,Zhou S,Li W,Tang M,Shi Y,Yi W,Cao Y

更新日期：2007-08-01 00:00:00

abstract：:Lamivudine therapy often causes breakthrough of hepatitis B virus (HBV) DNA and breakthrough hepatitis. The aim of this study was to determine the viral factors that relate to HBV-DNA breakthrough with and without breakthrough hepatitis. Among 82 patients with chronic hepatitis B (CHB) who received lamivudine at a dos...

journal_title：Journal of medical virology

authors： Horiike N,Duong TN,Michitaka K,Joko K,Hiasa Y,Konishi I,Yano M,Onji M

更新日期：2007-07-01 00:00:00